What Clexane is used for
Clexane is used in a number of medical conditions. It is used to:
treat blood clots
treat certain types of heart disease (eg. angina and heart attacks), when used with aspirin
prevent blood clots forming after an operation, during hospitalisation or extended bed rest or during purification of the blood by an artificial kidney (haemodialysis).
Clexane is one of a group of medicines called low molecular weight heparins (LMWH). These medicines work by reducing blood clotting activity.
Your doctor may have prescribed Clexane for another reason.
Ask your doctor if you have any questions about why Clexane has been prescribed for you.
There is no evidence that Clexane is addictive.
This medicine is only available with a doctor’s prescription.
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food shop.
Some medicines and Clexane may interfere with each other. These include:
medicines or substances used to prevent and treat blood clots
medicines containing aspirin or salicylates
Dextran 40, a medicine use to treat shock
medicines used to treat inflammatory disease, such as oral non-steroidal anti-inflammatory medicines or corticosteroids.
If any of these medicines are used while using Clexane, careful monitoring of your blood clotting factors is required by your doctor.
These medicines may be affected by Clexane or may affect how well it works. You may need to use different amounts of your medicine or you may need to use different medicines. Your doctor or pharmacist will advise you.
Your doctor and pharmacist may have more information on medicines to be careful with or avoid while using Clexane.
How to use it
How much to use
Your doctor will decide what dose you will receive. This depends on your condition and other factors, such as your weight.
For the prevention of blood clots, the following are the usual doses, which are administered by injection under the skin once a day:
moderate risk patients: 20mg
high risk patients: 40mg
For the treatment of blood clots which have formed in the leg/deep vein,
the usual dose is 1mg/kg body weight twice a day or 1.5mg/kg body weight once a day injected under the skin. Warfarin sodium therapy is usually started within 72 hours of Clexane by your doctor.
For patients that require dialysis,
the usual dose is 1mg/kg into the tubing of the dialysis machine at the start of the session. Additional doses may be given if required.
For treatment of severe heart attacks,
the usual dose is 30mg injected into a vein plus 1mg/kg injected under the skin, followed by 1mg/kg injected under the skin twice a day.
For treatment of certain other types of heart disease,
the usual dose is 1 mg/kg injected under the skin twice a day.
These doses of Clexane may be changed by your doctor. Your doctor will decide when and how much Clexane you will be given.
How to use it
Clexane is usually given by an injection under the skin or into the tubing of the dialysis machine. The recommended site for injection is the stomach area. A different injection site should be used for each injection. Do not rub the injection site after administration.
It may be given by your doctor, nurse or yourself. Your doctor will tell you how you will be given your injection.
Clexane can also be given by an injection into a vein. This will be done in hospital by your doctor or nurse.
The prefilled syringes are ready for use. The air bubble in the syringe should not be expelled.
Graduated Prefilled Syringes
When using the 60mg, 80mg, 100mg, 120mg and 150mg graduated syringes, the volume to be injected should be measured precisely according to the dosage recommended by your doctor.
The whole length of the syringe needle should be introduced vertically into the thickness of a skin fold gently held between the operator’s thumb and finger. This skin fold should be held throughout the duration of the injection.
Clexane does not contain any antimicrobial agents, so must be used once only and any residue discarded.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are using Clexane.
All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor if you notice any of the following and they worry you:
Pain, bruising or irritation at the injection site after Clexane has been given
- hard inflamed nodules at the injection site
- itchy red rash at the injection site
- bleeding at the injection site
- itchy skin
What it looks like
Clexane is available in the following range of presentations:
Ready to use Prefilled Syringes:
- 20mg/0.2mL, 10’s
- 40mg/0.4mL, 10’s
Ready to use Prefilled Syringes with graduated markings:
- 60mg/0.6mL, 10’s
- 80mg/0.8mL, 10’s
- 100mg/1.0mL, 10’s
- 120mg/0.8mL, 10’s
- 150mg/1.0mL, 10’s
Clexane contains enoxaparin sodium.
Clexane also contains water for injections.